Frontline NHS England staff will have to be fully vaccinated against Covid, the government is expected to announce.
A deadline will be set for next spring to give unvaccinated staff time to get both doses.
About 110,000 of more than 1.4 million healthcare workers in NHS England have not yet had a first Covid jab.
Thursday is the deadline for care home workers in England to get vaccinated.
The government’s decision follows a consultation which began in September and considered whether both the Covid and flu jabs should be compulsory for frontline NHS and care workers.
The flu vaccine will not be made mandatory and there will be exemptions for the Covid vaccine requirement for medical reasons.
Each of the four UK nations makes its own decisions on the issue.
Scotland, Wales and Northern Ireland have not made any proposals to make Covid jabs compulsory for NHS workers or care home staff.
Last month, Health Secretary SajidJavid said he was leaning towards compulsory vaccination for NHS staff in England, saying it was the right thing to do to protect staff and patients.
